目的探讨白细胞介素６（ＩＬ６）在老年女性原发性骨质疏松症（ＯＰ）发病机理中的作用。方法采用ＭＴＴ法检测９７例不同年龄组健康女性血清ＩＬ６活性以及骨密度的水平。结果随年龄的增加，女性的ＩＬ６活性逐渐升高，而骨密度值却逐渐下降，相关分析表明，两者呈明显的负相关（ｒ＝－０７２４，Ｐ＜００５）；绝经后女性的ＩＬ６活性与绝经前女性相比较，明显升高，而骨密度值却明显降低。结论ＩＬ６活性的升高与绝以后女性的骨丢失有关，ＩＬ６可能参与了ＯＰ的发病机理 Objective To investigate the role of interleukin-6 (IL-6) in the pathogenesis of primary osteoporosis (OP) in elderly women. Methods MTT was used to detect serum IL6 activity and bone mineral density in 97 healthy women of different ages. Results With the increase of age, the activity of IL6 in women gradually increased while the value of BMD decreased gradually. Correlation analysis showed that there was a significant negative correlation between them (r = -0724, P <005). Postmenopausal women of IL 6 activity and premenopausal women compared to significantly increased, while the value of bone mineral density was significantly reduced. Conclusions The increase of IL-6 activity is related to the bone loss in post-abortion women. IL-6 may be involved in the pathogenesis of OP