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慢性阻塞性肺疾病（ COPD）是我国常见病、多发病，发病率越来越高，其急性加重多由感染引起，核心是气道炎症。在炎症反复刺激过程中，不断的启动凝血纤溶系统，凝血功能改变，致血液高凝状态，即血栓前状态（ PTS）。这种血栓前状态极易并发深静脉血栓、肺栓塞及心血管事件等。因此，COPD患者早期及时进行抗凝治疗越来越受到临床医生的重视，而低分子量肝素治疗是临床较为成熟安全有效的抗凝治疗措施。“,”Chronic obstructive pulmonary disease( COPD) is a common disease and frequently-occurring disease in our country, Its incidence trends to raise year by year,acute exacerbations of Chronic obstructive pulmonary diseases(AECOPD) is usually caused by infection and pulmonary in flammation is the core.Inflammation of the stimulated repeatedly,start the blood coagulation systerm and fibrinolytic system,blood coagulation function is changed,lead to high blood coagulation state,also is Prethrombotic state(PTS). This state easily complicated by deep vein thrombosis、Pulmonary embolism、Cardiovascular events and so on.Therefore,early antico-agulant therapy more and more get the attention of the clinicians.And low-molecular-weight heparin anticoagulation therapy is safe and effective clinical anticoagulant therapy.