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治疗心脏疾病的药物,如洋地黄、奎尼丁、普鲁卡因酰胺、利多卡因、β-受体阻滞剂或β-受体刺激剂的药理和毒性作用,均已知悉。但很多药物,并不作为治疗心脏病用的,对心脏也有毒性作用,不仅会引起心电图的改变,甚至可造成突然死亡。本文对此作一复习,并对其毒性作用部位和机理加以介绍,特别着重于三环族抗抑郁剂和抗肿瘤剂柔毛霉素和阿霉素(Adriamyzin)。毒性作用的部位,可分别发生在传导系统、心肌和冠状动脉。 (1)心脏传导系统:可发生心律失常和传导阻滞。过去已知悉的药物有吐根素、氯奎、锑剂、磷剂、汞剂等。值得注意的是,近年来三环族抗抑郁剂的广泛应用,如甲胺噻嗪
The pharmacological and toxicological actions of drugs for treating heart diseases such as digitalis, quinidine, procainamide, lidocaine, beta-blockers or beta-receptor stimulants are known. But many drugs, not for the treatment of heart disease, have a toxic effect on the heart, not only can cause ECG changes, and even cause sudden death. This article reviews this and describes its site of action and mechanism of toxicity, with a particular emphasis on tricyclic antidepressants and antitumor agents daunorubicin and adriamyzin. The site of toxic effects can occur in the conduction system, myocardium and coronary arteries, respectively. (1) cardiac conduction system: arrhythmia and conduction block can occur. Past known drugs are ibuprofen, chloroquine, antimony agents, phosphorus agents, such as mercury agent. It is noteworthy that in recent years, the widespread use of tricyclic antidepressants, such as methylamine