给兔侧脑室注射阿托品有兴奋呼吸作用,且可增强毛果芸香碱、氨甲酰甲胆碱、槟榔碱兴奋呼吸效应;东莨菪碱对呼吸影响不明显,但却可拮抗毛果芸香碱、氨甲酰甲胆碱、槟榔碱兴奋呼吸效应。阿托品与东莨菪碱对呼吸影响不同的原因可能与选择性阻滞中枢不同亚型M受体有关。侧脑室注射阿托品似有减慢心率倾向,东莨菪碱对心率影响不明显,但均可拮抗以上拟胆碱药的心率减慢作用。 The injection of atropine into the lateral ventricle of rabbits stimulated the respiration, and enhanced the pirn, carbachol, arecoline excitatory respiration; scopolamine had no significant effect on respiration, but it could antagonize pilocarpine, bethanechol, betel nut Alkali excited breathing effect. Atropine and scopolamine on the respiratory effects of different may be selective block central different M receptor. Intracerebroventricular injection of atropine seems to slow down the heart rate, scopolamine had no significant effect on heart rate, but both antagonize the above slow down the role of cholinergic heart rate.