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目的:探讨胃癌患者的腹腔游离癌细胞及腹水癌胚抗原(CEA)、糖类抗原199(CA199)与临床病理的关系,为诊断及预后评估提供依据。方法:测定163例行根治性切除胃癌患者腹腔冲洗液CEA、CA199表达水平,并采用细胞学方法检测腹腔游离癌细胞。结果:当肿瘤浸透浆膜、有淋巴结转移时腹腔游离癌细胞检出率明显升高(P<0.05),游离癌细胞检出与否与有无脉管侵犯及神经侵犯无明显关系(P>0.05),游离癌细胞阳性与腹水CEA、CA199高低无明显相关性(P>0.05)。结论:腹腔游离癌细胞与肿瘤侵犯深度及淋巴结转移情况等临床病理特点密切相关,与腹水CEA、CA199无明显相关性。
OBJECTIVE: To investigate the relationship between the expression of CEA, CA199 and clinical pathology in patients with gastric cancer and to provide evidence for the diagnosis and prognosis evaluation. Methods: The expressions of CEA and CA199 in peritoneal irrigation fluid of 163 patients with radical resection of gastric cancer were measured. The free cells in peritoneal cavity were detected by cytology method. Results: The detection rate of free cancer cells in peritoneal cavity was significantly increased when the tumor infiltrated the serosal membrane and lymph node metastasis (P <0.05), and there was no significant correlation between the detection of free cancer cells and the presence or absence of vascular invasion and nerve invasion (P> 0.05). There was no significant correlation between the positive rate of free cancer cells and the levels of CEA and CA199 in ascites (P> 0.05). CONCLUSION: Free peritoneal cancer cells are closely related to clinicopathological features such as tumor invasion depth and lymph node metastasis, and have no significant correlation with ascites CEA and CA199.