论文部分内容阅读
目的探讨急性心肌梗死(AMI)合并类风湿关节炎(RA)与不合并类风湿关节(RA)患者的临床指标及血清白介素-6(IL-6)水平和外周血辅助性T细胞17(Th17)的差异。方法选择合并RA的AMI患者28例,不合并RA的AMI患者28例,收集这些患者的基线资料,并测定患者血清IL-6水平和外周血淋巴细胞Th17细胞亚群,比较2组差异。结果合并RA的AMI患者血清IL-6水平高于不合并RA的AMI患者(P<0.05),身体质量指数(BMI)低于不合并RA的AMI患者(P<0.05);Th17细胞在AMI患者外周血CD 4 T细胞中比例显著升高,但在合并及不合并RA的AMI患者中无统计学意义;合并RA的AMI患者的血清IL-6水平显著高于不合并RA的AMI患者,且在不合并RA的AMI患者中,血清IL-6水平与AMI患者冠脉病变程度呈正相关(P<0.05)。结论血清IL-6可能是不合并RA的AMI患者冠脉病变进展的重要炎症因子,而Th17细胞可能是RA患者发生AMI的一个潜在致病因素。
Objective To investigate the clinical significance of the serum levels of interleukin-6 (IL-6) and peripheral blood helper T cells in patients with acute myocardial infarction (AMI) complicated with rheumatoid arthritis (RA) and rheumatoid arthritis (RA) ) Of the difference. Methods Twenty-eight AMI patients with RA and 28 AMI patients without RA were enrolled. Baseline data of these patients were collected. Serum IL-6 levels and peripheral blood lymphocyte subsets of Th17 cells were measured and compared between the two groups. Results The level of serum IL-6 in AMI patients with RA was higher than that in AMI patients without RA (P <0.05), and the body mass index (BMI) was lower in AMI patients without RA (P <0.05) The proportion of CD 4 T cells in peripheral blood increased significantly, but there was no significant difference in AMI patients with or without RA. Serum IL-6 levels in AMI patients with RA were significantly higher than AMI patients without RA In patients with AMI without RA, serum IL-6 levels were positively correlated with the severity of coronary lesions in patients with AMI (P <0.05). Conclusion Serum IL-6 may be an important inflammatory factor in progression of coronary artery disease in patients with AMI without RA, and Th17 cells may be a potential risk factor for AMI in RA patients.