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目的探讨卡托普利联合硝苯地平治疗妊娠高血压综合征患者的临床疗效。方法选取2013年3月至2014年3月辽宁省朝阳市中医院收治的80例妊娠高血压综合征患者,按随机数字表法将其分为对照组与研究组,各40例。对照组患者给予硝苯地平,研究组患者在对照组基础上口服卡托普利,比较两组患者的临床疗效、血压改善情况、不良反应发生情况及生命质量情况。结果研究组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后,研究组患者的SBP、DBP均明显低于对照组,差异均有统计学意义(均P<0.05);研究组患者的不良反应发生率明显低于对照组,差异有统计学意义(P<0.05);研究组患者的生理功能(PF)、生理职能(RP)、躯体疼痛(BP)、一般健康状况(GH)、精力(VT)、社会功能(SF)、情感职能(RE)、精神健康(MH)评分均明显高于对照组,差异均有统计学意义(均P<0.05)。结论卡托普利联合硝苯地平治疗妊娠高血压综合征患者临床疗效明显,可有效改善患者的血压水平及生命质量,且产后不良反应发生率低。
Objective To investigate the clinical efficacy of captopril combined with nifedipine in the treatment of patients with pregnancy induced hypertension. Methods From March 2013 to March 2014, 80 cases of pregnancy induced hypertension syndrome admitted to Chaoyang Hospital of Traditional Chinese Medicine from Liaoning Province were divided into control group and study group according to random number table method, 40 cases in each group. Patients in the control group were given nifedipine. Patients in the study group were given captopril orally on the basis of the control group. The clinical efficacy, the improvement of blood pressure, the incidence of adverse reactions and the quality of life of the two groups were compared. Results The total effective rate of treatment in study group was significantly higher than that in control group (P <0.05). After treatment, SBP and DBP in study group were significantly lower than those in control group (P <0.05) (P <0.05). The incidence of adverse reactions in the study group was significantly lower than that in the control group (P <0.05). The patients in the study group had significantly lower rates of physical function (PF), physical function (RP), somatic pain (BP), general health (GH), energy (VT), social function (SF), emotional function (RE) and mental health (MH) were significantly higher than those of the control group (all P < 0.05). Conclusion Captopril combined with nifedipine in the treatment of patients with pregnancy-induced hypertension syndrome has obvious curative effect, which can effectively improve the patients’ blood pressure and quality of life, and the incidence of postpartum adverse reactions is low.