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目的:观察中风方联合西医疗法治疗缺血性脑卒中恢复期患者对高纤维蛋白原血症及中医证候的影响。方法:将符合纳入标准的70例缺血性脑卒中恢复期气虚血瘀证患者随机分为治疗组与对照组各35例。治疗组在常规治疗(低盐低脂饮食、控制基础疾病、康复锻炼、抗血小板聚集、降脂)的基础上,加予中风方;对照组只采用常规治疗。2组疗程均为4周。观察治疗前后纤维蛋白原(Fib)水平、中医证候积分及治疗过程中的不良反应发生情况等。结果:治疗后,2组中医证候积分均较治疗前下降,治疗组治疗前后积分差值大于对照组,差异均有统计学意义(P<0.01)。治疗组中医证候疗效总有效率为62.9%,高于对照组的总有效率(11.4%)(P<0.01)。治疗组Fib水平较治疗前降低,差异有统计学意义(P<0.01);对照组Fib水平治疗前后比较,差异无统计学意义(P>0.05);治疗组治疗前后Fib差值大于对照组,差异有统计学意义(P<0.01)。Fib控制效果:治疗组总有效率为20.0%,对照组总有效率为0,2组比较,差异有统计学意义(P<0.01)。治疗组阳性Fib转阴率(71.4%)高于对照组(5.71%)(P<0.01)。2组患者在治疗期间均未见不良反应情况出现。结论:采用中风方联合西医疗法治疗缺血性脑卒中恢复期患者较单纯西医疗法在改善高纤维蛋白原血症和临床症状方面更有优势。
Objective: To observe the effect of stroke combined with Western medical treatment of patients with high recovery of ischemic stroke on fibrinogen hyperlipidemia and TCM syndromes. Methods: A total of 70 patients with Qi-deficiency and Blood-stasis Syndrome that conformed to the inclusion criteria were randomly divided into treatment group and control group with 35 cases in each group. The treatment group was added to stroke on the basis of routine treatment (low-salt low-fat diet, control of underlying diseases, rehabilitation exercise, anti-platelet aggregation, lipid-lowering); the control group was treated only routinely. The two courses of treatment were 4 weeks. Before and after treatment to observe the level of fibrinogen (Fib), TCM syndrome score and the incidence of adverse reactions in the course of treatment. Results: After treatment, the scores of TCM syndromes in two groups decreased compared with those before treatment, and the differences of scores of the two groups before and after treatment were greater than those of the control group (P <0.01). The total effective rate of TCM syndromes in treatment group was 62.9%, higher than that in control group (11.4%) (P <0.01). The level of Fib in the treatment group was lower than that in the control group before treatment (P <0.01), but there was no significant difference in the level of Fib in the control group before and after treatment (P> 0.05) The difference was statistically significant (P <0.01). Fib control effect: The total effective rate was 20.0% in the treatment group, the total effective rate in the control group was 0 and 2, the difference was statistically significant (P <0.01). The positive rate of Fib in treatment group (71.4%) was higher than that in control group (5.71%) (P <0.01). No adverse reactions occurred in the two groups during the treatment. Conclusion: Stroke combined with Western medical treatment of patients with ischemic stroke recovery than Western medicine alone in the treatment of hyper fibrinogenmia and clinical symptoms more advantages.