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目的探讨热休克蛋白70(HSP70)与急性心肌梗死(AMI)后心室重构的相关性。方法 78例急性心肌梗死患者,根据6个月后左室舒张末期容积指数是否较基线值增加20%将其分为左室重构(LVR)组和非左室重构(NLVR)组。入院后第2天清晨空腹测静脉血中的HSP70,发病第3天和6个月分别行心脏超声心动图测定左室舒张末期容积(LVEDV)。结果 LVR组中HSP70水平高于NLVR组,差异具有统计学意义(P<0.05),LVR组中HSP70水平与LVEDV呈正相关(P<0.05)。结论 AMI后HSP70的表达参与了左室重构的发生,对左室重构有一定的预测价值。
Objective To investigate the correlation between heat shock protein 70 (HSP70) and ventricular remodeling after acute myocardial infarction (AMI). Methods 78 patients with acute myocardial infarction were divided into left ventricular remodeling (LVR) group and non-left ventricular remodeling (NLVR) group according to whether left ventricular end-diastolic volume index increased by 20% after 6 months. On the second day after admission, the fasting venous blood HSP70 was measured on the second day and the left ventricular end-diastolic volume (LVEDV) was measured by echocardiography on the third day and the sixth month after onset. Results The level of HSP70 in LVR group was significantly higher than that in NLVR group (P <0.05). The level of HSP70 in LVR group was positively correlated with LVEDV (P <0.05). Conclusion The expression of HSP70 is involved in the occurrence of left ventricular remodeling after AMI, and has certain predictive value for left ventricular remodeling.