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雄激素受体的多少与成骨细胞的数量有关。刺激骨髓基质细胞表面的雄激素受体可抑制破骨细胞在骨髓腔的分化。雄激素不仅抑制破骨细胞的发生,而且通过刺激骨膜促进皮质骨的形成。临床上雄激素对于青春期骨量的增加以及其青春期后骨量的维持起到关键性的作用。因此,雄激素替代治疗对于性腺机能减退的男性患者是非常必要的。然而,雄激素替代治疗对部分雄激素缺乏患者的作用尚不清楚。迄今为止,只有睾酮在雄激素替代治疗方面有确切的疗效。但仍需要进一步的临床和基础研究,以明确雄激素对抗雌激素受体的刺激在男性骨骼内环境稳定方面发挥选择性作用。
Androgen receptor number and the number of osteoblasts. To stimulate androgen receptor on the surface of bone marrow stromal cells can inhibit the differentiation of osteoclasts in the bone marrow cavity. Androgen not only inhibits the occurrence of osteoclasts, but also stimulates the formation of cortical bone by stimulating the periosteum. Androgen clinically plays a key role in the increase of bone mass in adolescence and the maintenance of bone mass after puberty. Therefore, androgen replacement therapy is very necessary for male patients with hypogonadism. However, the role of androgen replacement therapy in some androgen-deficient patients is not clear. To date, only testosterone has definite efficacy in androgen replacement therapy. However, further clinical and basic research is still needed to clarify that androgen stimulation of the estrogen receptor plays a selective role in the stabilization of male skeletal homeostasis.