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高速泳动族蛋白1(high-mobility group box 1,HMGB1)是一种高度保守的DNA结合蛋白,具有维持核小体结构和调节基因转录的功能,近来发现它是炎性反应强有力的促炎因子。在大多炎性疾病,特别是脓毒症病例中,HMGB1的血清和组织水平均显著升高,而且它与其受体如糖基化终末产物受体(receptor for advanced glycation end products,RAGE)、Toll样受体4(toll-like receptor,TLR4)、Toll样受体2(TLR2)等相互作用促进炎性疾病的发展。为了进一步了解HMGB1,本文就HMGB1的结构、生物学活性、与免疫细胞相互作用、细胞表面受体、以及拮抗HMGB1的药物等进行综述。
High-mobility group box 1 (HMGB1) is a highly conserved DNA-binding protein with the function of maintaining nucleosome structure and regulating gene transcription. It has recently been found that HMGB1 is a strong pro-inflammatory response Inflammatory factor. In most inflammatory diseases, especially in sepsis, serum and tissue levels of HMGB1 are significantly elevated, and are correlated with their receptors such as receptor for advanced glycation end products (RAGE) Toll-like receptor 4 (TLR4), Toll-like receptor 2 (TLR2) and other interactions promote the development of inflammatory diseases. In order to further understand the HMGB1, this article reviews the structure, biological activity, interaction with immune cells, cell surface receptors, and drugs that antagonize HMGB1.