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目的探讨血管紧张素ⅡⅠ型受体抑制剂氯沙坦预防及治疗氯化钙诱导的腹主动脉瘤的作用机制。方法选用血管旁孵育高浓度氯化钙诱发的小鼠腹主动脉瘤模型,利用病理学以及血管超声学等方法进行研究。结果预防性地给予氯沙坦不仅能够抑制血管扩张,减小血管的最大外径,保护血管结构完整;同时对于已经形成的腹主动脉瘤,氯沙坦还能够阻止其进行性发展。结论氯沙坦预防并治疗腹主动脉瘤的作用可能与其能够调节血管组织局部免疫微环境并且抑制炎性细胞浸润,减轻血管损伤,调节血管重构及改善纤维化的程度有关。氯沙坦可能是阻止腹主动脉瘤发生发展潜在的治疗药物。
Objective To investigate the mechanism of losartan, an angiotensin Ⅱ type 1 receptor inhibitor, in the prevention and treatment of calcium-induced abdominal aortic aneurysm. Methods The model of abdominal aortic aneurysm induced by high concentration of calcium chloride in blood was used to incubate the abdominal aortic aneurysm. The pathological and vascular ultrasound were used to study the model. Results Losartan not only prevented the vasodilatation, but also reduced the maximum diameter of the blood vessel to protect the integrity of the blood vessel structure. At the same time, Losartan could prevent the progressive development of the established abdominal aortic aneurysm. Conclusion Losartan prevents and treats abdominal aortic aneurysm. The effect of losartan on the prevention and treatment of abdominal aortic aneurysm may be related to its ability to regulate the local immune microenvironment of vascular tissue and inhibit inflammatory cell infiltration, reduce vascular injury, regulate vascular remodeling and improve fibrosis. Losartan may be a potential therapeutic to prevent the development of abdominal aortic aneurysm.