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小鼠连续7d分别ip大黄素、大黄酸和芦荟大黄素42,47,44mg/kg后,使肝微粒体细胞色素F-450含量分别比对照组下降41.7,51.9,66.3%,使戊巴比妥钠诱导的小鼠睡眠时间分别比对照组延长18.7,81.8,64.3%。大黄素、大黄酸、芦荟大黄素、大黄酚和大黄素甲醚结合于氧化态细胞色素P-450的差示光谱均为Ⅱ型光谱。上述结果表明:大黄蒽醌衍生物是一类细胞色素P-450抑制剂,可能减缓NADPH对细胞色素P-450的还原作用,影响肝脏药物氧化代谢功能。
After mice were treated with ip emodin, rhein and aloe-emodin at the concentrations of 42, 47, and 44 mg/kg for 7 days, the content of cytochrome F-450 in liver microsomes was decreased by 41.7, 51.9, and 66.3%, respectively, compared with the control group. Sodium-induced nausea increased sleep duration by 18.7, 81.8, and 64.3%, respectively, compared with the control group. The differential spectra of emodin, rhein, aloe-emodin, chrysophanol, and rheux monomethyl ether bound to oxidation state cytochrome P-450 were all type II spectra. The above results indicate that rhubarb is a class of cytochrome P-450 inhibitors that may slow down the reduction of cytochrome P-450 by NADPH and affect the liver’s oxidative metabolism.