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目的:观察西比灵加用治疗难治性癫(?)的疗效。方法:采用加用自身对照法,对２５例难治性癫(?)在原用抗癫(?)药物不变的基础上,加用西比灵(每晚５~１０ｍｇ)辅助治疗。主要观察治疗前后发作频率的改善情况、不良反应以及其对原用抗癫(?)药物血药浓度的影响。结果:２５例经加用西比灵治疗后,发作频度较加用前减少≥５０%者１２例,总有效率４８%,其中５例发作频度较加用前减少≥７５%;不良反应较少,仅２例表现为头昏、乏力,１例表现为恶心,且症状均较轻,减量后消失;加用西比灵前后原基础抗癫(?)药物血浓度监测无明显变化;ＥＥＧ好转１４例(６３．６%)。结论:西比灵可作为治疗癫(?)的辅药,且不影响其他抗癫(?)药物的血药浓度。
Objective: To observe the effect of xibingling in treating refractory epilepsy (?). Methods: 25 cases of intractable epilepsy (?) Were treated with xbalin (5 ~ 10mg per night) on the basis of the same antiepileptic drugs. The main observation before and after treatment to improve the frequency of seizures, adverse reactions and the original anti-epileptic (?) Drug blood drug concentration. Results: After 25 cases were treated with xipinine, the frequency of seizure was reduced by 50% or more in 12 cases, the total effective rate was 48%. The frequency of seizures in 5 cases was reduced by 75% Reaction was less, only 2 cases showed dizziness, fatigue, 1 case showed nausea, and the symptoms are lighter, weight loss disappeared; plus anti-seizure before and after treatment with xibinger baseline anti-epileptic drug serum concentration was no significant Change; EEG improved in 14 cases (63.6%). Conclusion: Sibelium can be used as adjuvant in the treatment of epilepsy ()) without affecting the plasma concentrations of other antiepileptic drugs.