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目的调查分析45~50岁北京市居民甲状腺结节患病与碘营养状况的相关性。方法于2014年在北京市4个区的体检中心随机抽样方法选取1 041名45~50岁正常体检人群,问卷调查人口学信息及甲状腺结节发病可能的危险因素,收集晨尿测定尿碘含量,B超诊断甲状腺结节情况。结果共收集调查对象1 041人,总人群尿碘为1.3~2 660.4μg/L,中位数为143.3μg/L,男性尿碘中位数(154.2μg/L)高于女性(127.3μg/L),郊区(158.8μg/L)高于城区(113.8μg/L),差异均有统计学意义(均P<0.05);B超共检出有甲状腺结节者366人(甲状腺结节组),占35.2%,女性检出率(43.9%)高于男性(28.2%);甲状腺结节组尿碘中位数为134.9μg/L,对照组尿碘中位数为145.8μg/L,2者差异无统计学意义;logistic回归分析结果显示,女性(OR=1.903)和遗传因素(OR=2.300)为患有甲状腺结节的危险因素。结论北京市45~50岁居民碘营养水平处于适宜范围,而甲状腺结节患病率较高,甲状腺结节的高发与碘摄入量的不足或过量无统计学意义,其危险因素仍需进一步研究。
Objective To investigate the correlation between thyroid nodules and iodine nutrition among 45-50-year-olds in Beijing. Methods A total of 1041 healthy people aged 45-50 years old were selected from the physical examination centers of 4 districts in Beijing in 2014 to investigate the demographic information and possible risk factors of thyroid nodules. Urine iodine , B ultrasound diagnosis of thyroid nodules. Results A total of 1 041 subjects were enrolled in this study. The total urinary iodine was 1.3-2 660.4 μg / L, with a median of 143.3 μg / L. The median urinary iodine was higher in men (154.2 μg / L) than in women (127.3 μg / L), and suburban (158.8μg / L) were higher than those in urban area (113.8μg / L) (all P <0.05); 366 thyroid nodules ), Accounting for 35.2%. The detection rate of female (43.9%) was higher than that of male (28.2%). The median urinary iodine in thyroid nodule was 134.9μg / L, and the median urinary iodine in control group was 145.8μg / The difference between the two groups was not statistically significant. Logistic regression analysis showed that female (OR = 1.903) and genetic (OR = 2.300) were the risk factors of thyroid nodules. Conclusion The iodine nutrition of residents aged 45-50 years in Beijing is in the suitable range, and the prevalence of thyroid nodules is high. The high incidence of thyroid nodules and iodine intake or insufficiency is not statistically significant. The risk factors still need further the study.