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１９９１～１９９８年，我们对荆州区川店镇５０３名６～１５月龄儿童进行了现行沪１９１麻疹疫苗血清流行病学效果观察，结果表明，初次免疫后１个月麻疹ＩｇＧ抗体阳转率为９１６５％，ＧＭＴ为１∶２６６７４，达保护滴度者比例为４６５％。随着时间的推移，第４年上述指标迅速下降到４６８６％、１∶１２７４和１８５％，第６年时低至２９４３％、１∶４８９和１３６％。０２ｍｌ、０３ｍｌ和０５ｍｌ麻疹疫苗组的近期和远期效果是类似的，初免后１个月时ＩｇＧ滴度越高，其免疫持久性越好；初免月龄是影响麻苗免疫效果的主要原因，６月龄初免组的免疫效果明显低于≥８月龄组。结果提示麻苗８月龄初免是可行的。
From 1991 to 1998, we observed the epidemiological effect of the existing Shanghai-191 measles vaccine on 503 children aged 6 ~ 15 months in Chuandian Town, Jingzhou District. The results showed that the positive rate of measles IgG antibody in the first month after primary immunization was 9165%, GMT 1:266 74, the proportion of protection of titers 46 5%. Over time, the above indicators rapidly dropped to 4686%, 1:1274 and 185% in the fourth year, to 2943% in the sixth year, to 1:489 and to 1.36 %. The short-term and long-term effects of the 02ml, 03ml and 05ml measles vaccine groups were similar, and the higher the IgG titer at 1 month after the first immunization was, the better their immune persistence was; The main reason of immune effect of Miao Miao, the immune effect of 6 M early immunization group was significantly lower than the> 8 M group. The results suggest that 8-month-old Miao Miao is feasible.