River basin is a special region with the characteristics of entirety and relation, regionality and diversity,gradation and network, openness and dissipation etc. It is an important unit that organizes and governs nationaleconomy as well as a natural region. In river basin, all natural essential factors relate closely each other, and there isremarkable influence between inter-regions. In the process of developing river basin, the multiplex main interest body,the diverse interest demand and the multi-ways of interest realization constitute a complicated interest network, and resultin various contradictions and conflicts. Therefore, effective regional interest coordination mechanism should be estab-lished to coordinate various regional interest relations. They are the public interest realization mechanism, the fairinterest assignment mechanism, the effective interest integration mechanism, the expedited interest expression mecha-nism and the reasonable interest compensative mechanism. River basin is a special region with the characteristics of entirety and relation, regionality and diversity, gradation and network, openness and dissipation etc. It is an important unit that organizes and governs nationaleconomy as well as a natural region. In river basin, all natural essential factors respect closely each other, and there is notmarkable influence between inter-regions. In the process of developing river basin, the multiplex main interest body, the diverse interest demand and the multi-ways of interest substantive constitute a complicated interest network, and resultin Various contradictions and conflicts. They are the public interest realization mechanism, the fair interest assignment mechanism, the effective interest integration mechanism, the expedited interest expression mecha-nism and the reasonable interest compensative mechanism.