论文部分内容阅读
目的 :研究PTCA后防止动脉再狭窄。方法 :用PTCA导管的气囊剥脱兔腹主动脉内皮。损伤后给药组 (6只 ) ,于损伤后立即由PTCA导管注入复方当归液 16ml(2 5 %当归注射液 15ml+ 2 0 %丹参注射液 1ml) ,以后每日经耳静脉注射给药 1次 ,最后 1次给药为取材当日。损伤组 (6只 ) ,于损伤后 ,与损伤后给药组同期注射生理盐水 16ml。两组分别于损伤后 2 4h及 96h取出腹主动脉 ,制作标本 ,供扫描电镜下观察。结果 :气囊已造成兔腹主动脉内皮剥脱。损伤组损伤后 2 4h及 96h时 ,动脉内皮下层的裸露胶原组织上有大量血小板附着。而损伤后给药组于损伤后 2 4h及 96h时 ,血管内皮下层光滑 ,只有极少数血小板附着。结论 :复方当归液具有防止血小板在胶原组织上附着的作用 ,对保护血管内膜 ,防止或降低再狭窄的发生有重要意义
Objective: To study the prevention of restenosis after PTCA. METHODS: The abdominal aorta endothelium of rabbits was peeled off with a PTCA catheter balloon. In the post-injury administration group (6 rats), the compound Angelica sinensis was injected into the PTCA catheter 16ml immediately after injury (25% of Angelica sinensis injection 15ml + 20% Salvia miltiorrhiza injection 1ml), and then once daily via the auricular vein injection once The last dose was the day of collection. In the injury group (6 rats), after injury, 16 ml normal saline was injected in the same period as the post-injury administration group. In the two groups, the abdominal aorta was removed at 24 hours and 96 hours after injury, and specimens were prepared for observation under a scanning electron microscope. RESULTS: Balloons had caused endothelial apposition of the abdominal aorta in rabbits. At 24 h and 96 h after injury, there was a large amount of platelet adhesion on the bare collagenous tissue of the subendothelial arteries. In the post-injury group at 24 hours and 96 hours after injury, the vascular endothelium was smooth, and only a few platelets adhered. Conclusion : The compound Angelica sinensis has the effect of preventing platelet adhesion on the collagen tissue, and it is of great significance to protect the vascular intima and prevent or reduce the occurrence of restenosis.