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目的探讨重组人干扰素α-2b凝胶降低尖锐湿疣复发率的疗效。方法选择60例尖锐湿疣患者随机分为两组,对照组应用单纯高频电灼法去除疣体,治疗组在对照组基础上加用重组人干扰素α-2b凝胶,连续观察12周。结果 4周后两组的复发率比较差异无统计学意义(P>0.05);8周及12周后治疗组的复发率均明显低于对照组,两组比较差异均有统计学意义(P<0.05)。总复发率:12周后治疗组复发率为33.3%,对照组复发率为63.3%。治疗组复发率明显低于对照组(P<0.05)。治疗组在整个治疗过程中未发生严重不良反应。结论重组人干扰素α-2b凝胶能显著降低尖锐湿疣的复发率,且安全性高。
Objective To investigate the efficacy of recombinant human interferon α-2b gel in reducing the recurrence rate of condyloma acuminatum. Methods Sixty patients with condyloma acuminatum were randomly divided into two groups. The control group was treated with high frequency electrocautery to remove the wart. The treatment group was treated with recombinant human interferon α-2b gel for 12 weeks. Results There was no significant difference in relapse rate between the two groups after 4 weeks (P> 0.05). The recurrence rates of the two groups were significantly lower than those of the control group after 8 and 12 weeks (P <0.05). The total relapse rate: The recurrence rate was 33.3% in the treatment group after 12 weeks and 63.3% in the control group. The recurrence rate of the treatment group was significantly lower than that of the control group (P <0.05). The treatment group in the entire course of treatment without serious adverse reactions. Conclusions Recombinant human interferon α-2b gel can significantly reduce the recurrence rate of condyloma acuminatum and is safe.