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目的:探讨输尿管镜联合气压弹道碎石在肝内胆管结石临床治疗中的应用价值。方法以2012年1月至2014年10月广东省东莞市企石医院收治的100例肝内外胆管结石患者为研究对象,根据肝内胆管结石处理方式分为两组,分别进行输尿管镜联合气压弹道碎石(观察组)和开腹取石手术(对照组)。比较两组术中术后情况、临床疗效及并发症情况。结果两组手术时间比较差异无统计学意义(t=1.397,P>0.05)。观察组术中出血量、住院时间均明显低于对照组,差异有统计学意义(t=2.813、2.285,P<0.05)。观察组与对照组临床疗效、并发症发生情况比较,差异均有统计学意义(净石率、残石率、二期手术χ2值分别为8.796、5.782、7.451,胆漏、出血、胆道感染、总发生率χ2值分别为5.364、4.793、3.902、6.587,P0 . 05 ) . In the observation group , blood loss and duration of hospital stay were significantly lower than those of the control group (P<0.05). Comparison of the clinical efficacy and the complications occurred of the observation group and the control group, the difference was statistically significant (the net rate of stone, the rate of residual stone, second stage surgery values ofχ2 were 8.796, 5.782, and 7.451, respectively; the bile leakage, bleeding, biliary tract infection, total incidence values of χ2 were 5.364, 4.793, 3.902, and 6.587, respectively, P<0.05). Conclusion Combined combined pneumatic lithotripsy and ureteroscopy treatment of hepatolithiasis has good efficacy, with less trauma and fewer complications, and is worthy of promotion.