Fresh air age is an important index to evaluate indoor environment. The conventional method for measuring or calculating fresh air age is only suitable for simple ventilation systems and not for central ventilation systems. In this paper, an algorithm for calculating fresh air age in central ventilation system is presented, which is based on the analysis of air flow in duct and air mixing. An example is given to illustrate the algorithm. The fresh air age in every ventilated room and duct can be acquired after all rooms and duct are directly calculated in t without iteration. The algorithm is suitable for different central ventilation systems.