本文报道36例慢性粒细胞白血病(慢粒)患者,经间歇大剂量马利兰治疗后,与31例常规疗法相比较,近期疗效优于常规疗法组。但远期疗效观察,急变发生率为61%,急变发生时间平均在确诊后34.7个月,中位生存期31.25个月,与常规小剂量连续给药组相比较,无显著性差异。 This article reports 36 patients with chronic myeloid leukemia (CML) patients, after intermittent high-dose treatment of Maryland, compared with 31 cases of conventional therapy, the recent curative effect is better than the conventional therapy group. However, the long-term efficacy of observation, the incidence of sudden change was 61%, the average time of onset of acute change 34.7 months after diagnosis, the median survival of 31.25 months, compared with the conventional low-dose continuous administration group, no significant difference.