论文部分内容阅读
目的观察耐多药结核患者对氧氟沙星(Ofx)、丁胺卡那霉素(Am)二线抗结核药物的敏感性,为临床治疗和防治提供理论依据。方法选取2014年3月—2015年9月兰州市肺科医院接诊的90例耐多药结核病患者进行研究。采用硝基苯甲酸法进行菌株鉴定,应用比例法进行药敏试验,分析耐药情况。结果 90例耐多药患者中,对Ofx和Am的耐药率分别为27.78%和12.22%,Ofx的耐药率明显高于Am,其差异有统计学意义(P<0.05)。同时耐Ofx和Am的患者3例,占3.33%。不同类型、不同性别以及不同年龄组的耐多药结核患者对Ofx和Am的耐药率差异无统计学意义(P>0.05)。但初治和复治患者、男性、中年组患者对Ofx和Am耐药率相对较高。结论临床实践中应规范使用Ofx和Am,避免结核病患者产生广泛耐药。
Objective To investigate the susceptibility of second-line anti-tuberculosis drugs (OFx) and amikacin (Am) in patients with multidrug-resistant tuberculosis (MDR-TB) to provide a theoretical basis for clinical treatment and prevention. Methods From March 2014 to September 2015, 90 cases of MDR-TB patients admitted to Lanzhou Pulmonary Hospital were studied. Using nitrobenzoic acid method for strain identification, the proportion method for susceptibility testing, analysis of drug resistance. Results Among 90 MDR-resistant patients, the resistance rates to Ofx and Am were 27.78% and 12.22% respectively, and the drug resistance of Ofx was significantly higher than that of Am (P <0.05). Ofx and Am resistant patients in 3 cases, accounting for 3.33%. The resistance rates of Ofx and Am in MDR-TB patients of different genders, genders and different age groups were not significantly different (P> 0.05). However, the initial and retreatment patients, male, middle-aged patients resistant to Ofx and Am relatively high. Conclusion Ofx and Am should be standardized in clinical practice to avoid widespread drug resistance in TB patients.