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目的 提高对促纤维化小圆细胞肿瘤的认识和诊断水平。 方法 回顾性总结本病 2例患者的临床、病理资料 ,结合文献分析该肿瘤的发病情况、组织来源、病理特征、免疫组织化学、诊治及预后。 结果 该肿瘤临床表现复杂多样 ,病理检查肿瘤细胞呈小圆形、核深染、胞浆少且无特殊排列的巢状 ,其间有大量增生的纤维结缔组织。免疫组织化学检测上皮、神经、肌、间质的相关蛋白细胞角蛋白、上皮膜抗原、结蛋白、神经原特异性烯醇化酶、波形蛋白表达阳性。 2例均于术后 9个月内相继死亡。 结论 该肿瘤临床表现多样 ,常规检查不能正确诊断 ,必须进行免疫组化检测确诊。大多预后险恶。
Objective To improve the understanding and diagnosis of fibroinflammatocytoma. Methods The clinical and pathological data of 2 patients with this disease were retrospectively reviewed. The incidence of the tumor, the source of the tissue, the pathological features, the immunohistochemistry, the diagnosis and treatment and the prognosis were analyzed. Results The clinical manifestations of the tumor were complex and diverse. The pathological examination of the tumor cells showed a small round shape, deep stained nuclei, few cysts and no special nests. In the meantime, there was a large number of fibrous connective tissue with hyperplasia. Immunohistochemical detection of epithelial, nerve, muscle, interstitial related protein cytokeratin, epithelial membrane antigen, desmin, neuron specific enolase, vimentin positive expression. Both cases died within 9 months after operation. Conclusion The clinical manifestations of the tumor are diverse, routine examination can not be correctly diagnosed, and immunohistochemical examination must be performed to confirm the diagnosis. Most prognosis is sinister.