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通过对卫生部北京生物制品研究所1994～1996年A群脑膜炎球菌多糖疫苗生产有关数据的统计分析认为，1996年多糖原液鲎试验（LAL）合格率下降的原因是细菌大罐培养后期菌体自溶，脂多糖（LPS）污染了多糖原液。SDS-PAGE银染法测定多糖原液中LPS含量偏高的结果支持这一结论．
According to the statistical analysis of the data of Group A meningococcal polysaccharide vaccine production from 1994 to 1996 by the Beijing Institute of Biological Products of the Ministry of Health, it is considered that the reason of the passing rate of LAL in 1996 is that bacterial cells Autolysis, lipopolysaccharide (LPS) contaminated the polysaccharide solution. SDS-PAGE silver staining method to determine the LPS content of polysaccharide solution in high results support this conclusion.