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目的:观察甘陆散敷脐联合大黄解毒汤保留灌肠治疗乙型肝炎后肝硬化腹水疗效。方法:将100例乙肝后肝硬化腹水患者按入院顺序随机分为治疗组和对照组,每组50例。对照组予西医常规综合治疗;治疗组在西医常规综合治疗基础上,采用甘陆散敷脐联合大黄解毒汤保留灌肠治疗。两组疗程均为10天,3个疗程后评价两组患者治疗前后临床症状、体重、腹围、24h尿量、肝肾功、血凝试验、电解质、血浆内毒素、腹部B超变化,并评价不良反应。结果:治疗组总有效率为88%,优于对照组的82%,差异有统计学意义(P<0.01),治疗组肝功能及症状体征改善优于对照组(P<0.05,P<0.01)。治疗组降低血浆内毒素疗效优于对照组(P<0.01)。结论:甘陆散敷脐联合大黄解毒汤保留灌肠治疗乙型肝炎后肝硬化腹水操作简单、疗效显著、且安全、无明显毒副作用。
Objective: To observe the curative effect of Ganluosan Fuzhu Umbilical combined with Dazhuang Jiedu Decoction retention enema in the treatment of post-hepatitis B cirrhosis ascites. Methods: 100 patients with posthepatitic cirrhosis ascites were randomly divided into treatment group and control group according to hospital admission order, with 50 cases in each group. The control group was given routine western medicine treatment. The treatment group was treated with the traditional Chinese medicine combined conventional treatment with Ganlushuji umbilical combined with rhubarb and detoxification decoction. The two groups were treated for 10 days. The clinical symptoms, body weight, abdominal circumference, 24h urine output, liver and kidney function, hemagglutination test, electrolytes, plasma endotoxin, abdominal B-ultrasound changes before and after treatment were evaluated after 3 courses Evaluation of adverse reactions. Results: The total effective rate was 88% in the treatment group, which was better than 82% in the control group (P <0.01). The improvement of liver function and symptoms and signs in the treatment group was better than that in the control group (P <0.05, P <0.01) ). The therapeutic effect of reducing plasma endotoxin in the treatment group was better than that in the control group (P <0.01). CONCLUSION: Ganluisan Umbilicus combined with Dazhuang Jiedu Decoction for retention enema is simple, effective and safe in the treatment of posthepatitic cirrhosis with ascites. It has no obvious side effects.