论文部分内容阅读
目的：探讨内皮素（ＥＴ）、一氧化氮（ＮＯ）及两者关系在正常妊娠生理和妊高征病理生理变化中的作用。方法：应用放射免疫法和Ｇｒｅｉｓｓ法测定２０名正常未孕妇女（ＮＮＰ组）、２０名正常孕晚期妇女（ＮＬＰ组）和３５名妊高征患者（ＰＩＨ组）的血浆ＥＴ和血清ＮＯ值，并加以比较。结果：ＮＬＰ组与ＮＮＰ组相比，血浆ＥＴ和血清ＮＯ水平均显著升高（Ｐ＜０．０１），但二者比值无明显变化（Ｐ＞０．０５）。中、重度ＰＩＨ组与ＮＬＰ组相比，ＥＴ水平显著升高（Ｐ＜０．０１），ＮＯ水平显著降低（Ｐ＜０．０１）。各ＰＩＨ组ＥＴ／ＮＯ值均显著高于ＮＬＰ组（Ｐ＜０．０１）。中、重度ＰＩＨ组ＥＴ／ＮＯ值显著高于轻度ＰＩＨ组（Ｐ＜０．０１）。在中、重度ＰＩＨ组中，ＥＴ与ＮＯ呈显著负相关。结论：ＥＴ增高、ＮＯ降低，二者间平衡失调在妊高征病理生理变化中起重要作用。
Objective: To investigate the role of endothelin (ET) and nitric oxide (NO) in the pathophysiological changes of normal pregnancy and pregnancy induced hypertension. Methods: Plasma ET and serum NO levels were measured by radioimmunoassay and Greiss method in 20 normal pregnant women (NNP group), 20 normal pregnant women (NLP group) and 35 PIH patients (PIH group) And compare them. Results: Compared with NNP group, the levels of plasma ET and serum NO in NLP group were significantly increased (P <0.01), but there was no significant difference between the two groups (P> 0.05). Compared with NLP group, ET level was significantly increased in moderate and severe PIH group (P <0.01) and NO level was significantly decreased (P <0.01). ET / NO in each PIH group was significantly higher than that in NLP group (P <0.01). The ET / NO in moderate and severe PIH group was significantly higher than that in mild PIH group (P <0.01). In moderate and severe PIH group, ET and NO showed a significant negative correlation. Conclusion: ET increased, NO decreased, the imbalance between the two plays an important role in the pathophysiological changes of pregnancy induced hypertension.