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目的观察阿托伐他汀与血栓通注射液联合治疗脑梗死患者对其血脂及血流动力学影响。方法入选68例脑梗死患者,分为试验组34例和对照组34例。对照组口服阿托伐他汀钙每天20 mg,试验组在对照组基础上联合血栓通注射液450 mg,2周为一个疗程。比较2组患者治疗前,治疗1个月后的神经功能缺损程度,血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)血脂指标及血浆比黏度、全血比黏度、全血还原黏度、红细胞聚集指数、纤维蛋白原、红细胞积压血流动力学指标变化,以及治疗后的临床疗效。结果治疗后,上述指标比较后,试验组总有效率(91.18%)显著高于对照组(67.65%)(P<0.05)。结论阿托伐他汀与血栓通注射液联合治疗脑梗死能明显改善患者的血脂及血流动力学,有利于患者神经功能的恢复,且不良反应发生率低。
Objective To observe the effects of atorvastatin and Xueshuantong injection on blood lipid and hemodynamics in patients with cerebral infarction. Methods Sixty-eight patients with cerebral infarction were enrolled and divided into experimental group (34 cases) and control group (34 cases). Control group oral atorvastatin calcium 20 mg daily, the experimental group in the control group on the basis of Xueshuantong injection 450 mg, 2 weeks for a course of treatment. The levels of neurological impairment, serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol C) blood lipid index and plasma specific viscosity, whole blood viscosity, whole blood viscosity reduction, erythrocyte aggregation index, fibrinogen, red blood cell hemoperfusion index changes, and the clinical efficacy after treatment. Results After treatment, the total effective rate (91.18%) in the experimental group was significantly higher than that in the control group (67.65%) after the above indexes were compared (P <0.05). Conclusions Atorvastatin combined with Xueshuantong injection can significantly improve the blood lipids and hemodynamics in patients with cerebral infarction, which is beneficial to the recovery of neurological function and the incidence of adverse reactions is low.