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目的:探讨乙肝前S1抗原(pre-S1)在几种常见乙肝模式患者鉴别诊断中的临床价值。方法:对353例乙肝两对半不同模式的患者血清及50例全阴对照组血清,同步进行pre-S1及HBV-DNA检测。结果:在HB-sAg(+)、HBeAg(+)、HBcAb(+)模式组,pre-S1检出率为85.7%,HBV-DNA检出率为87.8%;在HBsAg(+)、HBcAb(+)、HBeAb(+)模式组,pre-S1检出率为53.9%,HBV-DNA检出率为49.4%;在HBsAg(+)、HBeAg(+)模式组,pre-S1检出率为78.3%,HBV-DNA检出率为80.0%;在HBsAg(+)、HBcAb(+)模式组,pre-S1检出率为28.6%,HBV-DNA检出率为24.5%;在HBsAg(+)、HBeAg(+)、HBeAb(+)模式组,pre-S1检出率为16.7%,HBV-DNA检出率为0.0%;在其他模式组,pre-S1和HBV-DNA检出率均为0.0%。结论:乙肝前S1抗原可作为HBV在体内复制的可靠标志。
Objective: To investigate the clinical value of pre-S1 pre-S1 in the differential diagnosis of several common hepatitis B patients. Methods: Serum of 353 patients with two pairs and half of different modes of hepatitis B and serum of 50 patients with full negative control were detected simultaneously with pre-S1 and HBV-DNA. Results: The detection rate of pre-S1 was 85.7% and the positive rate of HBV-DNA was 87.8% in HBsAg (+), HBeAg (+) and HBcAb (+ The detection rate of pre-S1 was 53.9% and the detection rate of HBV-DNA was 49.4% in HBeAg (+) and HBeAb (+) groups. The detection rate of pre-S1 in HBsAg (+) and HBeAg The detection rate of HBV-DNA was 78.3%, the detection rate of HBV-DNA was 80.0%. The detection rate of pre-S1 was 28.6% in HBsAg (+) and HBcAb (+ ), HBeAg (+), HBeAb (+) model group, pre-S1 detection rate was 16.7%, HBV-DNA detection rate was 0.0% 0.0%. Conclusion: Pre-S1 antigen can be used as a reliable marker of HBV replication in vivo.