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应用OKT系列单克隆抗体对39例支气管哮喘病儿外周血T细胞亚群进行检测。结果发现,各型哮喘病儿均有T细胞亚群异常,发作期病儿T抑制/杀伤亚群细胞降低和T辅助/诱导亚群细胞增高同时存在,而间歇期病儿仅有T抑制/杀伤亚群细胞降低;发作期和间歇期病儿T辅助细胞/T抑制细胞比值均显著增高,发作期和间歇期病儿外周血中双标记细胞也明显增高。提示T细胞亚群异常为哮喘病儿的原发改变,可能为其免疫失调的内在基础。
OKT series of monoclonal antibodies were used in 39 cases of children with bronchial asthma peripheral blood T cell subsets were detected. The results showed that all types of asthma children have T cell subsets abnormalities, the onset of sick children T suppressor / killing subpopulation reduction and T helper / induced subpopulation increased, while only intermittent sick child T inhibition / Kill the subpopulation decreased, the percentage of T-helper cells / T-suppressor cells was significantly increased in the attacking and intermittent periods, and the number of double-labeled cells in the peripheral blood was also significantly increased in the attacking and intermittent periods. Tip abnormal T cell subsets as a primary change in children with asthma may be the underlying basis of their immune disorders.