Based on the characteristic that the potential sliding surfaces of rock slope are commonly in the shape of either line or fold line, analysis thought of conventional pile foundation in the flat ground under complex load condition was applied and the upper-bound theorem of limit analysis was used to compute thrust of rock layers with all possible distribution shapes. The interaction of slope and pile was considered design load in terms of slope thrust, and the finite difference method was derived to calculate inner-force and displacement of bridge pile foundation in rock slope under complex load condition. The result of example shows that the distribution model of slope thrust has certain impact on displacement and inner-force of bridge pile foundation. The maximum displacement growth rate reaches 54% and the maximum moment and shear growth rates reach only 15% and 20%, respectively, but the trends of inner-force and displacement of bridge pile foundation are basically the same as those of the conventional pile foundation in the flat ground. When the piles bear the same level lateral thrust, the distribution shapes of slope thrust have different influence on inner-force of pile foundation, especially the rectangle distribution, and the triangle thrust has the smallest displacement and inner-force of pile foundation.