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目的探讨休克期开始连续性肾脏替代治疗(CRRT)在肾综合征出血热(HFRS)合并急性肾功能衰竭(ARF)患者治疗中的作用。方法对48例进行单纯血液透析、33例进行持续血液净化治疗的重型HFRS患者的临床资料进行回顾分析,比较两种治疗治疗效果。结果休克期开始采用CRRT治疗后重型出血热临床治愈32例,死亡1例。CRRT联合IHD治疗的患者死亡率、少尿期持续时间、多尿期持续时间、以及总住院时间较单纯IHD治疗的患者明显低,差异有统计学意义(P<0.05)。结论早期应用连续血液净化(CRRT)治疗重型HFRS急性肾衰竭,可降低病死率,缩短病程。
Objective To investigate the role of continuous renal replacement therapy (CRRT) in the treatment of patients with hemorrhagic fever with renal syndrome (HFRS) complicated with acute renal failure (ARF) at the start of shock. Methods The clinical data of 48 patients with hemodialysis and 33 patients with severe HFRS who underwent continuous hemodialysis were retrospectively analyzed. The therapeutic effects of the two treatments were compared. Results Thirty-two patients died of severe hemorrhagic fever after CRRT. Mortality, duration of oliguria, duration of polyuria, and total hospital stay in patients treated with CRRT combined with IHD were significantly lower than those treated with IHD alone (P <0.05). Conclusions Early treatment of severe HFRS with acute renal failure by continuous blood purification (CRRT) can reduce the mortality and shorten the course of the disease.