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目的探讨血清癌胚抗原(CEA)在结直肠癌进展及免疫治疗中的作用。方法随机选取68例初治结直肠癌患者为观察组,同期60例健康体检者为对照组。检测两组的CEA含量,分析阳性率。结果观察组患者CEA含量明显高于对照组(P<0.01)。68例结直肠癌患者中CEA阳性者23例(33.8%),23例患者治疗后CEA含量较治疗前明显降低(P<0.05),其中有20例(87.0%)恢复至正常水平。结论 CEA检测可作为结直肠癌早期诊断和治疗的一个敏感性指标,但其相关机制及预后价值有待在临床扩大样本进一步研究证实。
Objective To investigate the role of serum carcinoembryonic antigen (CEA) in the progression of colorectal cancer and immunotherapy. Methods A total of 68 patients with newly diagnosed colorectal cancer were randomly selected as observation group and 60 healthy people as control group. CEA levels in both groups were detected and the positive rate was analyzed. Results The CEA content in the observation group was significantly higher than that in the control group (P <0.01). Among 68 patients with colorectal cancer, CEA was positive in 23 patients (33.8%). The CEA content in 23 patients was significantly lower than that before treatment (P <0.05), of which 20 patients (87.0%) returned to their normal levels. Conclusions CEA test can be used as a sensitive indicator of early diagnosis and treatment of colorectal cancer, but the relevant mechanism and prognostic value need to be further confirmed in clinical expanded samples.