自从六十年代初,随着络合物化学、高分子化学及离子交换树脂的发展,配位体离子交换树脂被用来成功地解决了许多化合物的分离和提纯问题。例如,用于分离性质非常相似的几何异构体、同系物,甚至同位素和光学异构体。五十年代初已成功地应用离子交换树脂将外消旋对映体拆分为光学活性化合物。1968年达文柯夫等提出在不对称的配位体离子交换树脂 Since the early 1960s, with the development of complex chemistry, polymer chemistry and ion exchange resins, ligand ion exchange resins have been used successfully to solve the problem of separation and purification of many compounds. For example, for the separation of geometric isomers, homologues, and even isotopes and optical isomers of very similar nature. Racemic enantiomers have been successfully resolved into optically active compounds using ion exchange resins in the early 1950s. In 1968 Davenkov et al. Proposed asymmetric ligand ion exchange resins