葡萄糖酸钙片的溶出度测定美国药典21版已收载,其方法的溶出介质为900ml水;浆法50×g 45 min溶出度不得少于95%。含量测定为原子吸收光谱法。该法操作繁锁、不利推广。经实验,我们选用EDTA-Na液滴定法,测定国内产品10批,均达到美国药典要求,现报道如下: 仪器及试药仪器天津RC-Ⅱ型溶出度测定仪(天津大学无线电厂)。试药葡萄糖酸钙(山东新华药厂优级品,批号8302512);钙素红、EDTA-2Na均为分析纯。标准曲线的制备精密称取葡萄糖酸钙约0.5 g,置250 ml量瓶中,加水溶解并稀释至刻度,摇匀。分别精密吸取溶液1、2、3、4、5、6、7、8、9、10 ml,加水至 Determination of dissolution of calcium gluconate tablets The United States Pharmacopoeia 21 edition has been loaded, the method of dissolution medium is 900ml water; pulp 50 × g 45 min dissolution of not less than 95%. The content was determined by atomic absorption spectrometry. The method is cumbersome, unfavorable promotion. The experiment, we use EDTA-Na titration method, the determination of 10 batches of domestic products, have reached the United States Pharmacopoeia requirements are reported as follows: Instrument and reagent equipment Tianjin RC-Ⅱ dissolution tester (Tianjin University Radio Factory). Test calcium gluconate (Shandong Xinhua pharmaceutical superior quality products, lot number 8302512); Calcium red, EDTA-2Na were of analytical grade. Preparation of the standard curve Precision weighing about 0.5 g of calcium gluconate, set 250 ml volumetric flask, dissolved in water and diluted to the mark, shake. Precision drawing solution 1,2,3,4,5,6,7,8,9,10 ml, add water to