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我们在大鼠、猫、猴及人脑新纹状体尾侧,围绕苍白球颅外侧边缘,发现一个由纺锤形细胞构成的新区。根据它的位置命名为边缘区(MrD)。边缘区内富含多种神经递质。将大鼠脑Nissl切片用计算机三维结构重建技术,证明边缘区为一个位于新纹状体和苍白球之间的一个扁平盘状结构。用化学刺激诱导的c-Fos表达法证明边缘区和海马、杏仁核以及和认知功能有关的Meynert基底核之间存在机能及纤维联系。化学损伤大鼠两侧边缘区,用双盲法Y迷宫实验发现动物的学习记忆能力严重受损。活体人脑功能核磁共振检测,证明边缘区和前额叶同时参与了脑的学习记忆活动。我们的结果证明边缘区是哺乳动物脑内新发现的一个重要结构,其形态和纤维联系特殊。动物实验和活体功能核磁共振检测,证明边缘区的功能和脑的学习记忆密切相关。
We found a new zone of spindle cells around the caudal lateral margin of the globus pallidus in the caudal striatum of rats, cats, monkeys and human brains. According to its location named the marginal zone (MrD). Marginal zone is rich in a variety of neurotransmitters. The rat brain Nissl sections were reconstructed using computer 3D reconstruction and the marginal zone was found to be a flat disc-shaped structure between the new striatum and the globus pallidus. Chemostimulation-induced c-Fos expression demonstrated that there is a functional and fibrous connection between the marginal zone and the hippocampus, amygdala and Meynert’s basal nuclei associated with cognitive function. Chemical damage in both sides of the marginal zone, using a double-blind Y-maze test found that learning and memory in animals severely impaired. Living human brain function by magnetic resonance imaging, to prove that the marginal zone and prefrontal involvement of both brain learning and memory activities. Our results demonstrate that the marginal zone is an important newly discovered structure in the mammalian brain and that its morphology is associated with fibers. Animal experiments and in vivo functional magnetic resonance imaging showed that the function of the marginal zone is closely related to the learning and memory of the brain.