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美国 Merck公司的 1型人类免疫缺陷病毒 ( HIV- 1 ) gag疫苗 期试验结果不如在恒河猴中的结果。在猴子中的临床前研究显示 ,HIV- 1 gag DNA疫苗具有免疫原性 ,铝佐剂 Al PO4或非离子型嵌段共聚物 CRL1 0 0 5均能增强免疫应答。但在 3次 期临床试验中 ,356名受试者分别接受安?
US Merck’s type 1 human immunodeficiency virus (HIV-1) gag vaccine phase test results are not as good as in rhesus monkeys. Preclinical studies in monkeys show that the HIV-1 gag DNA vaccine is immunogenic and both the aluminum adjuvant Al PO4 or the non-ionic block copolymer CRL1 0 05 enhances the immune response. However, in the third phase of clinical trials, 356 subjects were receiving safety?