目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者外周血T细胞CD69表达率的检测及意义。方法:选择经PSG确诊的81例OSAHS患者,根据AHI指数分为轻、中、重度3组,每组27例;另选取27例无OSAHS的正常打鼾者为对照组。流式细胞术检测T细胞CD69表达率,分析T细胞CD69表达率与性别、年龄、BMI及PSG指标的相关性。结果:1OSAHS患者外周血T细胞CD69表达率随着鼾症程度上升逐渐增加(P<0.05);两两比较提示对照组与轻度组间T细胞CD69表达率无明显差别(t=1.649,P>0.05),其余组间比较均差异有统计学意义(P<0.05)。2OSAHS患者外周血T细胞CD69表达率与BMI、年龄、性别无相关性(P>0.05),与AHI呈正相关(P<0.01),与LSaO2呈负相关(P<0.01)。3联合手术及CPAP综合治疗的27例重度OSAHS患者AHI及外周血T细胞CD69表达率明显降低,LSaO2明显上升,差异有统计学意义(均P<0.01)。结论:外周血T细胞CD69表达率的上升可能为OSAHS并发心血管病的机制之一,T细胞CD69表达率的检测对反映OSAHS患者病情程度及评估并发心血管损害趋势具有一定的临床意义。 Objective: To investigate the significance of CD69 expression in peripheral blood T cells in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods: Eighty-one patients with OSAHS diagnosed by PSG were selected and divided into mild, moderate and severe groups according to AHI index, 27 in each group. Another 27 normal subjects with OSAHS were selected as control group. Flow cytometry was used to detect the expression of CD69 on T cells. The correlation between CD69 expression on T cells and sex, age, BMI and PSG was analyzed. Results: The expression of CD69 in peripheral blood mononuclear cells of patients with OSAHS increased gradually with the increase of snoring (P <0.05). The pairwise comparison showed that there was no significant difference in the expression of CD69 between control group and mild group (t = 1.649, P > 0.05), the other groups were statistically significant differences (P <0.05). There was no correlation between the expression of CD69 and BMI, age and sex (P> 0.05), but positively correlated with AHI (P <0.01) and negatively correlated with LSaO2 (P <0.01). 3 combined surgery and CPAP combined treatment of 27 cases of severe OSAHS patients with AHI and peripheral blood T cell CD69 expression was significantly lower, LSaO2 increased significantly, the difference was statistically significant (P <0.01). CONCLUSION: The increase of CD69 expression in peripheral blood T cells may be one of the mechanisms of OSAHS complicated by cardiovascular disease. The detection of CD69 expression in T cells is of clinical significance in reflecting the severity of OSAHS and assessing the trend of cardiovascular damage.