细胞核因子-κB(nuclearfactorofkappaB,NF-κB)是一种重要的转录调节因子。1956年由Sen和Baltimore等[1]从成熟的B淋巴细胞中提取的一种能与免疫球蛋白κ轻链基因增强子特定κB部位结合的蛋白质。许多研究证实,NF-κB与免疫应激,细胞分化,细胞周期调控,细胞凋亡及恶性肿瘤有关 Nuclear factor-kappa B (NF-κB) is an important transcriptional regulator. In 1956, Sen and Baltimore et al [1] extracted from mature B lymphocytes, a protein that binds to the specific κB site of the immunoglobulin κ light chain gene enhancer. Many studies have confirmed that NF-κB is associated with immune stress, cell differentiation, cell cycle regulation, apoptosis and malignancy