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目的:比较观察大剂量血浆联合人血白蛋白针治疗重型肝炎[1]与血浆置换治疗重型肝炎的疗效。方法:两组均采用类似的内科基础治疗[2],联合组为大剂量血浆联合人血白蛋白针,对照组采用血浆置换[3]。结果:两组肝功能均明显改善:ALT、AST、TBiL、GGT、ALP等均明显下降,凝血常规:PT下降(恢复正常)与PTA升高(恢复正常)均差别不大。结论:大剂量血浆置换联合人血白蛋白针与血浆置换对重型肝炎患者的治疗均可明显改善患者的病情,降低死亡率,且前者在住院费用上明显优于后者。
OBJECTIVE: To compare the efficacy of high-dose plasma plus human albumin in the treatment of severe hepatitis [1] and plasma exchange in the treatment of severe hepatitis. Methods: Both groups were treated with similar medical basic therapy [2], the combined group was high-dose plasma combined with human serum albumin needle, and the control group was treated with plasma exchange [3]. Results: The liver function of both groups improved obviously: the levels of ALT, AST, TBiL, GGT and ALP decreased significantly. Coagulation routine: PT decreased (returned to normal) and PTA increased (returned to normal). Conclusion: The treatment of patients with severe hepatitis by high-dose plasma exchange combined with human serum albumin and plasma exchange can significantly improve the patient’s condition and reduce the mortality rate, and the former is obviously superior to the latter in the cost of hospitalization.