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目的 比较丙种球蛋白(IVIG)联合地塞米松(Dxm)与单独用地塞米松治疗特发性血小板减少性紫癜(ITP)的效果。方法 治疗组IVIG400mg·kg-1·d-1+Dxmlmg·kg-1·d-1静滴5天。对照组Dxmlmg·kg-1·d-1静滴连用5天。结果:治疗组:总反应率88.24％,平均止血天数1.07±0.96d.对照组:总反应率68.41％,平均止血天数2.4q±0.95d。治疗组血小板回升速度、幅度均显著快于对照组。结论:IVIG联合Dxm治疗急重症ITP的疗效优于单一Dxm治疗组。
Objective To compare the efficacy of gamma globulin (IVIG) with dexamethasone (Dxm) and dexamethasone alone in the treatment of idiopathic thrombocytopenic purpura (ITP). Methods The treatment group IVIG400mg · kg-1 · d-1 + Dxmlmg · kg-1 · d-1 infusion for 5 days. Control group Dxmlmg · kg-1 · d-1 infusion for 5 days. Results: In the treatment group, the overall response rate was 88.24% and the average number of days of hemostasis was 1.07 ± 0.96d. In the control group, the overall response rate was 68.41% and the average number of days of hemostasis was 2.4q ± 0.95d. The recovery rate and amplitude of platelet in the treatment group were significantly faster than those in the control group. Conclusion: The efficacy of IVIG combined with Dxm in the treatment of acute severe ITP is better than that of single Dxm treatment group.