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观察不同胰岛素制剂及应用方法对早期糖尿病肾病(DN)的影响。方法将50例早期DN患者随机分治疗组和对照组,治疗组使用胰岛素泵持续皮下输注射门冬胰岛素,对照组常规多次皮下注射胰岛素,2周后比较两组治疗前后尿白蛋白排泄率(UAER)及内生肌酐清除率(Ccr)的变化。结果两组治疗后UAER较治疗前均有下降(P<0.05),治疗组较对照组下降更为明显(P<0.05);两组治疗前后Ccr差异无显著性。结论胰岛素强化治疗能降低早期DN患者UAER,而胰岛素泵持续皮下输注射门冬胰岛素效果更为理想。
To observe the effect of different insulin preparations and application methods on early diabetic nephropathy (DN). Methods Fifty patients with early DN were randomly divided into treatment group and control group. Insulin pump was used to treat insulin aspart in the treatment group and insulin was administered subcutaneously in the control group. After two weeks, the urinary albumin excretion rate (UAER) and endogenous creatinine clearance (Ccr) changes. Results The UAER of both groups decreased after treatment (P <0.05), and decreased more significantly in the treatment group than in the control group (P <0.05). There was no significant difference in Ccr between the two groups before and after treatment. Conclusions Insulin intensive therapy can reduce UAER in patients with early DN, and insulin pump sustained insulin infusion subcutaneous insulin effect is more ideal.