酶抑制剂耐药的β-内酰胺酶(inhibitor-resistant TEM(IRT)β-lactamases)主要由大肠埃希菌、肺炎克雷伯菌和奇异变形杆菌等肠杆菌科细菌产生,对多种青霉素类及其复合抗菌药物耐药,产酶菌在临床中治疗难度增加,越来越引起临床医师的重视。本文就该酶的分类、表型特征、遗传特征、酶的结构与功能作了阐述。 Inhibitors of drug-resistant β-lactamase (inhibitor-resistant TEM (IRT) β-lactamases) mainly by Enterobacteriaceae, Klebsiella pneumoniae and Proteus mirabilis such as Enterobacteriaceae bacteria produce a variety of penicillins Class antibacterial drugs and antibiotics, enzyme-producing bacteria in clinical treatment more difficult, more and more attracted the attention of clinicians. In this paper, the classification of the enzyme, phenotypic characteristics, genetic characteristics, enzyme structure and function are described.