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目的评价新诊断的2型糖尿病(T2DM)患者胰岛素强化治疗前后氧化应激水平的变化。方法 30例新诊断的T2DM患者采用胰岛素泵强化治疗,治疗前后进行超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)水平测定。结果胰岛素泵强化治疗后,患者血浆中的SOD、GSH-Px水平明显上升(P<0.01)、MDA水平明显下降(P<0.01)。结论新诊断的T2DM患者胰岛素强化治疗后氧化应激水平明显降低。
Objective To evaluate the changes of oxidative stress in patients with newly diagnosed type 2 diabetes (T2DM) before and after intensive insulin treatment. Methods Thirty new cases of T2DM patients were treated with insulin pump. The levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) were measured before and after treatment. Results After intensive insulin treatment, the levels of SOD and GSH-Px in plasma increased significantly (P <0.01) and MDA levels decreased significantly (P <0.01). Conclusions Oxidative stress was significantly lower in patients with newly diagnosed T2DM after intensive insulin treatment.