论文部分内容阅读
二、肿瘤中出现的非随机染色体重排实际上是三类染色体位点的 DNA 序列重排。从图1与表3中,不难发现,在每一个染色体重排方式的两个染色体连接部位的断裂点上分布着与重排的启动、形成可能有关的DNA 序列,即细胞瘤基因和脆性部位。染色体易位是恶性肿瘤中的重要的重排方式。如前所述,85个肿瘤相关断裂点中就有65个是染色体易位的好发部位,居恶性肿瘤中染色体重排之首,因此,也是研究三类染色体位点序列重排的最好例证。表3是本研究根据第八届国际人类基因定位会议公布的44种染色体易位方式进
Second, the occurrence of non-random tumor chromosome rearrangement is actually three types of chromosomal DNA rearrangement site. From Figure 1 and Table 3, it is not difficult to find that in each chromosomal rearrangement of the two chromosomal junction breakpoints distributed with the start of rearrangement, the formation of DNA sequences that may be related to the tumor genes and brittle Site. Chromosomal translocations are important rearrangements in malignant tumors. As mentioned earlier, 65 of the 85 tumor-associated breakpoints are chromosomal translocations predominating in chromosomal rearrangements in malignant tumors and are therefore the best way to study the rearrangement of the three chromosomal loci illustration. Table 3 is based on the study of the Eighth International Human Genetics conference released 44 kinds of chromosomal translocation approach