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目的探讨高压氧治疗新生儿缺氧缺血性脑病(HIE)的临床疗效及期对预后的影响。方法根据是否进行高压氧治疗随机分为两组,高压氧组203例,对照组98例;两组综合治疗措施相同。高压氧治疗方法是按病情分时期进行。两组分别于生后第2、7、14天做3次行为神经测定(NBNA)以及动态系列各项检测以评价其近期疗效;远期随访至2～5岁的预后转归。结果以总有效率比较,高压氧组疗效明显优于对照组(P<0.005);高压氧组生后第7、14天的NBNA评分均明显高于对照组(P<0.05～0.01);生后2个月头颅CT复查比较,高压氧组发生长久性脑损害较对照组明显减少(P<0.01);以预后不良率比较,高压氧组为9.36%,对照组为25.51%,差异显著(P<0.01)。结论高压氧治疗HIE的近期临床疗效显著,远期预后转归明显改善。按病情分时期进行治疗比较适宜和安全。
Objective To investigate the clinical effects of hyperbaric oxygen therapy on neonatal hypoxic-ischemic encephalopathy (HIE) and its effect on prognosis. Methods According to whether hyperbaric oxygen therapy were randomly divided into two groups, hyperbaric oxygen group of 203 cases, control group of 98 cases; the two groups of the same treatment. Hyperbaric oxygen therapy is based on the disease sub-period. The two groups were performed behavioral nerve assay (NBNA) 3 times and dynamic series of tests on the 2nd, 7th and 14th days after birth respectively to evaluate their short-term curative effect. The long-term follow-up ranged from 2 to 5 years. Results The total effective rate of hyperbaric oxygen group was significantly better than that of the control group (P <0.005). The NBNA score of hyperbaric oxygen group was significantly higher than that of the control group on the 7th and 14th day (P <0.05 ~ 0.01) Compared with the control group, the long-term brain damage in hyperbaric oxygen group was significantly decreased (P <0.01). Compared with the control group, hyperbaric oxygen group was 9.36%, the difference was significant (P <0.01) P <0.01). Conclusions The recent clinical efficacy of hyperbaric oxygen in the treatment of HIE is significant, and prognosis of long-term prognosis is significantly improved. According to the disease sub-treatment for more appropriate and safe.