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乳腺癌是女性最常见的肿瘤相关性死亡原因之一,乳腺癌的免疫治疗已成为当前研究重点。多肽疫苗的主动免疫特异性刺激免疫系统诱导免疫反应,且能够有效降低自身免疫,在乳腺癌的治疗中受到越来越多的关注。HER-2过表达于乳腺癌细胞,因此可作为抗乳腺癌治疗的靶抗原。文章主要对乳腺癌相关抗原肽HER-2多肽疫苗的研究现状进行综述。
Breast cancer is one of the most common causes of cancer-related death in women, and breast cancer immunotherapy has become the focus of current research. Active immunization of peptide vaccine specifically stimulates the immune system to induce immune response, and can effectively reduce autoimmunity, which is receiving more and more attention in the treatment of breast cancer. HER-2 overexpression in breast cancer cells, it can be used as a target anti-breast cancer therapy. The article mainly reviews the research status of HER-2 polypeptide vaccine against breast cancer associated antigen peptide.