Major depressive disease (MDD) is one of the most common mental disorders and a leading cause of disability [1].Core symptoms include depressed mood, increased apathy, and a general loss of interest.In consequence, it represents not only a personal hardship for the patients themselves, but also a major socio-economic burden for society as a whole.In view of the low efficiency of the classic antidepressant drugs, it is most important to learn which pathophysiological events initiate MDD;this will make it possible to identify new therapeutic targets and eventually adequate pharmacological means to combat this disease.One of the difficulties in developing new anti-depressive pharmaceuticais is the inadequacy of the animal models used for this purpose.In humans, stressful life events including acute and chronic stress increase the risk for MDD [2].Because a laboratory animal correlate of MDD is not known, mice/rats are exposed to acute stress (e.g., tail suspension test, forced swim test, unavoidable foot shock test, social defeat test, or restraint stress) or chronic stress (chronic unpredictable stress) to induce depressive-like states [3, 4].