论文部分内容阅读
目的:探究七氟醚与丙泊酚在小儿麻醉脑氧代谢的影响。方法:选取韶关市第一人民医院于2012年1月至2014年5月收治的患儿70例,根据患儿麻醉维持中所用药物不同分为观察组和对照组,观察组采用七氟醚进行维持麻醉,对照组使用丙泊酚进行维持麻醉,观察两组患儿不同时间段的脑氧代谢指标,包括动脉血氧含量(CaO_2)、颈静脉血氧含量(Cjv O_2)、动脉-颈静脉血氧含量差(Ca-jv O_2)和脑氧摄取率(CERO_2)。结果:观察组患儿的Da-jv O_2和CERO_2两个指标在T2、T3、T4时期均明显低于对照组,且两组患儿的Da-jv O_2和CERO_2两个指标在T2、T3、T4时期均明显低于T1时期,T4时期两组患儿的Da-jv O_2和CERO_2均明显高于T2时期,组间比较,差异具有统计学意义(P<0.05)。结论:在小儿麻醉中使用七氟醚和丙泊酚均具有较好的麻醉效果,但七氟醚在降低脑氧代谢方面效果更加明显,对于降低脑组织缺氧、减少神经细胞损伤具有较好临床效果。
Objective: To investigate the effects of sevoflurane and propofol on cerebral oxygen metabolism in children. Methods: 70 cases of children admitted to the First People’s Hospital of Shaoguan City from January 2012 to May 2014 were divided into observation group and control group according to the different drugs used in anesthesia maintenance. The observation group was treated with sevoflurane The anesthesia was maintained in the control group. Propofol was used in the control group to maintain anesthesia. Cerebral oxygen metabolism indices (CaO 2, C jv O 2), arterio-jugular vein Low oxygen content (Ca-jv O 2) and cerebral oxygen uptake rate (CERO_2). Results: The two indicators of Da-jv O 2 and CERO 2 in the observation group were significantly lower than those in the control group at T2, T3 and T4, and Da-jv O_2 and CERO_2 in both groups were significantly higher at T2, T3, T4 were significantly lower than those in T1. The Da-jv O_2 and CERO_2 in both groups were significantly higher than those in T2 at T4 (P <0.05). CONCLUSIONS: Sevoflurane and propofol both have better anesthetic effects in pediatric anesthesia. However, sevoflurane is more effective in reducing cerebral oxygen metabolism and is better for reducing hypoxia in brain tissue and reducing neuronal damage Clinical effect.