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29例Ⅱ型糖尿病患者,分别接受糖肾平(15例)和D860(14例)双盲治疗4个月。在治疗前、后共作3次馒头餐试验,测定血清胰岛素、C肽和血糖水平,对比观察治疗前后和两组之间胰岛B细胞功能变化,并与正常组(15例)比较。结果表明,治疗前患者胰岛功能明显相对不足,餐后胰岛素分泌延缓,C肽/血糖比值低于正常。治疗后显著改善,空腹C肽/血糖比值正常。糖肾平在4个月疗程中主要通过改善胰岛功能而降血糖。
Twenty-nine patients with type 2 diabetes mellitus received double-blind treatment of Shushenping (15 cases) and D860 (14 cases) for 4 months respectively. Before and after treatment, a total of 3 times bread meal test, determination of serum insulin, C-peptide and blood glucose levels were compared before and after treatment and between two groups of pancreatic islet B cell function changes and compared with the normal group (15 cases). The results showed that patients before treatment was significantly less than the islet function, delayed postprandial insulin secretion, C peptide / blood glucose ratio lower than normal. After treatment, significant improvement, fasting C-peptide / blood glucose ratio was normal. Sugar kidney in the course of 4 months mainly through the improvement of pancreatic islet function and hypoglycemic.